Acute initial haemodynamic changes in a rat isoprenaline model of cardiotoxicity

Abstract

In this study, acute heamodynamic changes after s.c. administration of isoprenaline were followed. Shortly, ISO caused rapid decreases in afterload, preload, diastolic relaxation and filling while a short-term increase in left ventricle contractility was observed.

Similar experiments were performed with salbutamol and difference were discussed.

Keywords

• catecholamines
• diastolic dysfunction
• isoprenaline
• myocardial injury
• salbutamol