Publication at Faculty of Pharmacy in Hradec Králové, Faculty of Medicine in Hradec Králové |
2012
Abstract
The effect of dexrazoxane (DEX) on the catecholamine model of acute myocardial infarction was analyzed. DEX partly decreased the mortality, reduced myocardial calcium overload, histological impairment, and peripheral haemodynamic disturbances 24 h after isoprenaline administration.
Its protective effects are probably mediated by inhibition of late myocardial impairment and ventricular fibrillation likely due to inhibition of myocardial calcium overload. Complementary in vitro experiments suggested that iron chelation properties of DEX apparently did not play the major role.