Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity

Abstract

A new benzyldihydroisoquinoline alkaloid (1) was isolated from the tubers of Corydalis cava and named corylucinine. Additionally, 8-trichloromethyl-7,8-dihydropalmatine (2), an isolation artifact of tetrahydropalmatine, was obtained.

Both compounds showed only moderate inhibitory activity against HuAChE (IC50, (HuAChE) = 127.6 +/- 5.2 mu M for 1, and IC50, (HuAchE) = 82.9 +/- 3.9 mu M for 2) and none against HuBuChE.

Keywords

• Corydalis cava
• Corylucinine
• 8-Trichloromethyl-7,8-dihydropalmatine
• Acetylcholinesterase
• Butyrylcholinesterase
• Alzheimer's disease