Publication at Faculty of Medicine in Hradec Králové |
2012
Abstract
The presented in vitro experiment was focused on the influence of carrier medium / solvent (acetone or sunflower oil) on the basic characteristics of pyrene transfer through skin. Pyrene concentration in the donor phase was 0.00095 and 0.0095 g pyrene/g solvent.
The absorption of pyrene was in both donor phase concentrations higher in the case of using acetone solvent, but a statistically significant difference was only found after 12 and 24 hours of exposure at lower doses and after 12 hours of exposure at higher doses.