Development and optimization of methods for analysis of atorvastatin, rosuvastatin and its metabolites using UHPLC-MS/MS and MEPS sample preparation
2012
Abstract
Statins are used for lowering of the level of cholesterol in blood. They inhibit 3-hydroxy-3-methylglutaryl coenzyme A reductase, which is a key enzyme in endogene cholesterol synthesis.
Therefore, they are signifcant for the prevention of cardiovascular diseases. The method for simultaneous determination of atorvastatin, rosuvastatin and their metabolites using UHPLC-MS/MS was developed.
Microextraction approach MEPS was optimized for sample preparation.