The efficacy of allergen-specific immunotherapy in patients with atopic dermatitis who suffer in addition from allergic rhinitis or atopic bronchial asthma has been shown in a number of case reports and smaller cohort studies and in a larger multicentre trials with house dust mite immunotherapy. Allergen-specific immunotherapy to aeroallergenes may be useful in selected cases of atopic dermatitis alone but clear evidence of its efficacy is still lacking.
More larger prospective studies are now being performed in Europe which shall respond to the question if atopic dermatitis alone may be an indication for the initiation of specific immunotherapy.