Abstrakt
New methods for the determination of metoclopramide, antiemetic and gastroprokinetic pharmaceutical, were developed, using differential pulse voltammetry (DPV) and flow injection analysis (FIA) with amperometric detection on a boron-doped diamond film electrode. Electrode pretreatment necessary to ensure the stable results was investigated and it was found, that while DPV requires frequent electrode cleaning, FIA with a sufficiently high flow rate can maintain a stable signal with no signs of electrode passivation.
The calculated quantification limits of the DPV and FIA with amperometric detection were 0.13 mu mol L-1 and 0.015 mmol L-1, respectively. The applicability of the new methods was verified by the determination of metoclopramide in a pharmaceutical preparation.
FIA with amperometic detection proved to be sensitive, accurate and, due to the resistance of the electrode to the passivation, also simple to handle.