KIT Mutations and Sequence Changes in Genes Encoding SDH Complex Possibly Need Not be Mutually Exclusive in Gastrointestinal Stromal Tumors

Abstract

A small subset of gastrointestinal stromal tumors (GISTs) is associated with loss of function of the succinate dehydrogenase (SDH) complex of mitochondrial inner membrane proteins detectable as loss of subunit B (SDHB) immunostaining. This group of SDHB-deficient tumors encompasses several clinicopathologic entities.

Keywords

• succinate-dehydrogenase
• gastrointestinal stromal tumors