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KIT Mutations and Sequence Changes in Genes Encoding SDH Complex Possibly Need Not be Mutually Exclusive in Gastrointestinal Stromal Tumors

Publication at Faculty of Medicine in Pilsen |
2012

Abstract

A small subset of gastrointestinal stromal tumors (GISTs) is associated with loss of function of the succinate dehydrogenase (SDH) complex of mitochondrial inner membrane proteins detectable as loss of subunit B (SDHB) immunostaining. This group of SDHB-deficient tumors encompasses several clinicopathologic entities.