The non-invasive treatment of the diabetic maculopathy with hypolidpidemic agents with emphasis on the treatment with fibrates
Abstract
The diabetic macular edema (DME) results from many factors, among which donenates hyperglycemia, but dyslipidemia is also a contributing factor. It leads to a worse visual acuity, or if long standing, even to a permanent visual loss caused by the impaired layer of the junction of internal and external segments of photoreceptors (IS/OS junction) by edema.
According to the FIELD study, the DME may be favourably influenced by a noninvasive treatment with fibrates. Our case reports compare the use of fibrates and statins in the treatment of the DME.
In a patient treated with fibrates all symptoms of the DME resolved (disappearing of macular edema and detachment of IS/OS photoreceptors, reduction of hard exudates and the improvement of visual acuity of affected eye of 4 lines of ETDRS charts. We assume certain conditions for a succesful treatment with fibrates, especially a prompt initiation immediately after the diagnosis of diabetic macular edema without diabetic nephropathy.
The benefit of the treatment with fibrates is a non-invasive management of the DME, the prerequisite is a good cooperation between the diabetologist and the ophthalmologist.