A Comparison of Dequalinium Chloride Vaginal Tablets (Fluomizin) and Clindamycin Vaginal Cream in the Treatment of Bacterial Vaginosis: A Single-Blind, Randomized Clinical Trial of Efficacy and Safety

Abstrakt

To investigate if vaginal application of dequalinium chloride (DQC, Fluomizin) is as effective as vaginal clindamycin (CLM) in the treatment of bacterial vaginosis (BV). This was a multinational, multicenter, single-blind, randomized trial in 15 centers, including 321 women.

They were randomized to either vaginal DQC tablets or vaginal CLM cream. Follow-up visits were 1 week and 1 month after treatment.

Clinical cure based on Amseĺs criteria was the primary outcome. Secondary outcomes were rate of treatment failures and recurrences, incidence of post-treatment vulvovaginal candidosis (VVC), lactobacillary grade (LBG), total symptom score (TSC), and safety.

Klíčová slova

• Bacterial vaginosis
• Dequalinium chloride
• Clindamycin
• Vaginal infections
• Local therapy
• Pregnancy
• Fluomizin (R)