Abstract
Purpose Thrombolytic therapy in patients with acute ischemic stroke is contraindicated when the infarction core exceeds a given threshold. To date, there are no standardized guidelines for computed tomography infarction core assessment.
Current practice involves use of thresholding methods, where the results are further adjusted by an experienced physician. An automated method for infarction core delineation and volume measurement was developed and tested.
Materials and methods CT postprocessing software was developed for analysis of whole brain perfused blood volume (PBV) and cerebral blood volume (CBV) maps. The program was designed for potential use with mean transit time (MTT) or cerebral blood flow (CBF) maps.
The proposed method was tested on a set of 12 patients on both PBV and CBV maps with whole brain coverage by comparison with the results of a simple thresholding method and with manuály marked findings provided by two independent physicians. Results The proposed method produced a marked infarct core volume corresponding to 53% of the manually delineated volumes.
The simple thresholding method with the optimal threshold, using the same dataset,marked 15xlarger volume compared to the volume delineated by physicians. Conclusion An automated infarction core segmentation method based on local neighborhood features was developer and tested, demonstrating its utility in distinguishing between infarcted and non-infarcted areas, as well as reduction in the number of false positives and volume error.