Abstract
Sarcoidosis at the study of the Czech population, in comparsion with ACCESS study, has lesser sex related heterogenity,approximetely the same age distribution as american study with relatively frequent onset at older age. Our study group has tendency to lesser occurence of irreversible stadium IV and to more frequent absence of FVC impairment.
But DL impairment was found at nearly half of patients. As for the organ involvement, sarcoid arthritis, erythema nodosum and calcium metabolism alterations were most frequent.
Vital organs (neurologic, heart, kidneys) involvement was extremely rare. CD4/CD8 ratio in BAL>3.5, which is high specific for sarcoidosis, was present at more than 2/3 of our patients.
S-ACE elevations greater than two times the upper limits of normal, which could be helpful for diagnosis we observed at our patients only exceptionally.