Coupled expression of dipeptidyl peptidase-IV and fibroblast activation protein-alpha in transformed astrocytic cells
Abstract
Dipeptidyl peptidase-IV (DPP-IV) and Fibroblast activation protein-a (FAP) are speculated to participate in the regulation of multiple biological processes. The role of DPP-IV and FAP in the development and progression of various types of tumours, including glioblastoma, is intensively studied and their functional crosstalk is hypothesized.
Here we describe the correlative expression of DPP-IV and FAP mRNA in primary cell cultures derived from human glioblastoma and associated expression dynamics of both molecules in astrocytoma cell lines depending on culture conditions. Understanding of the expressional and functional coordination of DPP-IV and FAP may help clarify the mechanisms of biological roles of both molecules in transformed astrocytic cells.