Application of SNP array method in pranatal diagnosis

Abstract

SNP array (array method using Single Nucleotide Polymorphisms) enables to detect cytogenetically undetectable submicroscopic alterations (microdeletions, microduplications), which could be also causative for ultrasonographic anomalies of fetus. This article describes the principle, advantages, disadvantages and application possibilities of the SNP array method in prenatal diagnosis.

The ten month experience with SNP array use in prenatal diagnosis is presented. Our data suggest that SNP array analysis is a relevant and useful technique in prenatal diagnosis.

Keywords

• SNP array
• CNV
• prenatal diagnosis
• ultrasound diagnosis