Clonal evolution in chronic lymphocytic leukemia studied by interphase fluorescence in-situ hybridization

Abstract

The results of repeated interphase fluorescence in-situ hybridization (I-FISH, FISH) examination of 97 CLL patients and correlation of these findings with IgVH hypermutation status, ZAP-70 and CD38 expression are presented.

Keywords

• CLL
• FISH
• clonal evolution
• prognostic markers
• high-risk deletions