Abstract
Multiple sclerosis is associated with diverse neurobehavioral changes. The lifetime prevalence of depression approaches 50% in multiple sclerosis patients, prevalence of all types of anxiety disorder is at 36%, prevalence rates of bipolar disorder and psychosis are doubled when compared to the general population and pseudobulbar affect will afflict one in ten patients.
However, these disorders often respond well to treatment. This article reviews the treatment of these neurobehavioral disturbances.
Correct diagnosis and treatment can substantially improve the quality of life for multiple sclerosis patients. Neuropsychological studies have consistently demonstrated that 40-65% of patients with multiple sclerosis experience cognitive dysfunction.
Early detection of cognitive impairment is essential to enable therapeutic intervention to alleviate symptoms or prevent further cognitive decline, although how best to manage multiple sclerosis-related cognitive impairment still remains unclear.