The Effect of Pheochromocytoma Treatment on Subclinical Inflammation and Endocrine Function of Adipose Tissue
Abstract
The aim of our study was to evaluate the influence of surgical removal of pheochromocytoma on the endocrine function of adipose tissue and subclinical inflammation as measured by circulating C-reactive protein (CRP) levels. Eighteen patients with newly diagnosed pheochromocytoma were included into study.
Anthropometric measures, biochemical parameters, serum CRP, leptin, adiponectin and resistin levels were measured at the time of diagnosis and six months after surgical removal of pheochromocytoma. Surgical removal of pheochromocytoma significantly increased body weight, decreased BP, fasting blood glucose and glycated hemoglobin levels.
Serum CRP levels were decreased by 50% six months after surgical removal(p<0.05) despite a significant increase in body weight. Serum leptin, adiponectin and resistin levels were not affected by the surgery.