Pentosidine, an Advaced Glycation End_Product, May Reflect Clinical and Morphological Features and Hand Osteoarthritis
2012
Abstract
The study investigates pentosidine levels, an advanced glycation end-product, in patients with erosive and non-erosive hand osteoarthritis (HOA) and determine its potential association with clinical findings and imaging-defined joint damage. The levels of urine pentosidine, but not of serum pentosidine, were higher in patients with erosive HOA than in non-erosive HOA and correlated with CRP, and AUSCAN.
Serum pentosidine, but not in urine, significantly correlated with the Kallman radiographic score in erosive HOA at the baseline and after 2years. Our data suggest that serum and urine pentosidine levels may relate to the distinctive clinical and morphological features of HOA.