Serum concentration of hyaluronic acid correlates with the degree of fibrosis and portal hypertension
Abstract
Liver biopsy is a gold standard in the evaluation of liver diseases. Beside the diagnosis of liver diseases, liver biopsy is usually used to assess inflammatory activity and the degree of fibrotisation.
Recently, non-invasive parameters have been considered to substitute liver biopsy. The severity of fibrosis correlates with serum concentrations of some substances which are involved in the process of fibrotisation, like hyaluronic acid (HA), which is also part of the diagnostic Hepascore index.
Serum concentration of HA was described as elevated in patients with chronic HCV infection; less ínformation has been published regarding other liver diseases. The aim of our study was: to assess the diagnostic value of serum HA and Hepascore for the evaluation of fibrosis and portal hypertension in patients with liver disease of different aetiology.