Adipocyte heme oxygenase-1 induction attenuates metabolic syndrome in both male and female obese mice

Abstract

Increases in visceral fat are associated with increased inflammation, dyslipidemia, insulin resistance, glucose intolerance, and vascular dysfunction. We examined the effect of the potent heme oxygenase (HO)-1 inducer, cobalt protoporphyrin (CoPP), on regulation of adiposity and glucose levels in both female and male obese mice.

Both lean and obese mice were administered CoPP intraperitoneally (3 mg/kg once per week) for 6 weeks

Keywords

• adipocyte pAMPK
• female obesity
• heme oxygenase inducers
• inflammation