Recurrent chromosomal breakpoints in patients with myelodysplastic syndromes and complex karyotype versus fragile sites

Abstract

We confirmed co-localization of four breakpoints: 5q15, 5q33, 7q21.11 7q32.3 and FS in MDS patients. Their roles in clonal transformation are not yet fully characterized.

However, tumor-suppressor genes and/or oncogenes are predicted to reside in these loci. Further microarray analyses of the affected chromosomal regions in combination with molecular-cytogenetic approaches will help to elucidate the degree of correlation with fragile sites.

Keywords

• MDS
• microarray analysis
• complex karyotype
• fragile sites