The Assessment of Array Comparative Genomic Hybridization in Complex Karyotype Analyses

Abstract

Molecular-cytogenetic methods were used for analyses of complex genome rearrangements of malignant cells to specify them in more detail. Twelve samples of bone marrow cells of patients with myelodysplastic syndromes (MDS) and complex karyotype were examined by multicolor fluorescence in situ hybridization (mFISH), high-resolution multicolor banding (mBAND) and array comparative genomic hybridization (aCGH).

Combination of both approaches brought more detailed description of complex karyotypes and is highly recommended.

Keywords

• array comparative genomic hybridization
• multicolor fluorescence in situ hybridization
• myelodysplastic syndromes
• complex karyotype