Abstrakt
Pregnant women are often threatened by hypertension, symptoms of preterm labor, hepatopathy and other. These complications might be consequence of genetic factors together with involvement of enviromental factors.
We were searching for three polymorphisms Arg654Lys, Ala678Pro and Thr686Ala in exon 5, and two polymorphisms Phe802Leu, Ser827Ser/Leu in exon 7, and for the new mutations in exon 5 and 7 of the Pregnancy associated plasma protein-A gene in the studied group consisted of 203 women – 79 pregnant women in time of preterm labor, 24 pregnant women suffering from preeclampsia and 100 healthy pregnant and non-pregnant women serving as controls. We did not find any divergence from wild-type form of these polymorphisms in any of all studied groups, which lead us to the hypothesis, that these polymorphisms are not associated with our studied group of Caucasian origin.
However further studies with larger group of studied subjects are needed to confirm our results.