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Inhibition of the peptidyl-prolyl-isomerase pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RAR alpha and PML-RAR alpha

Publication at First Faculty of Medicine |


The peptidyl-prolyl-isomerase Pin1 interacts with phosphorylated proteins, altering their conformation. The retinoic acid receptor RAR alpha and the acute-promyelocytic-leukemia-specific counterpart PML-RAR alpha directly interact with Pin1.