Blood storage affects the detection of cellular prion protein on peripheral blood leukocytes and circulating dendritic cells in part by promoting platelet satellitism

Abstract

Our study demonstrates that the storage of blood prior to analysis greatly affects the detection of PrPc by flow cytometiy. To limit the inclusion of storage-generated artifacts, we recommend the processing of blood samples immediately after their collection. (C) 2012 Elsevier B.V.

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Keywords

• Flow cytometry
• Prion protein
• Blood storage
• Leukocytes
• Platelet satellitism