Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome
2010
Abstract
To identify cytogenetic risk factors predicting outcome in children with advanced myelodysplastic syndrome (MDS), overall survival (OS) of 192 children prospectively enrolled in EWOG-MDS studies was evaluated with regard to karyotypic complexity. The presence of a structurally complex karyotype was the strongest independent prognostic marker predicting poor outcome in children with advanced MDS.