The incidence of Candida infections is changing - the growth was dated from early eighties of 20th century till late nineties, but after fluconazole introduction a slow decrease of incidence of candidiasis was noted, mainly in hemato-oncological patients. In ICU patients, candidemia and invasive candidiasis remains still a serious problem with high incidence, and – among other causes of blood stream infections – reaching the highest mortality, as much as 40 – 50 %.