Protection of mice against influenza A and B virus infection by mucosal immunization with Bacillus firmus as an adjuvant

Abstract

Influenza is one of the important respiratory pathogens worldwide and vaccination is one of crucial intervention for reducing the spread and impact of this infection.The attention is therefore focused on vaccines that are able to induce cross-protection and could be effective also in case of sudden appearance of a new virus variant. Dead and delipitaded Bacillus firmus has been shown as a adjuvant induced efficient and even heterosubtypic cross-protection

Keywords

• influenza A virus
• mucosa
• immunization
• Bacillus firmus