Association of the -344T/C aldosterone synthase gene variant with essential hypertension

Abstract

The aldosterone synthase gene (CYP11B2) is an important candidate gene region in essential hypertension. We therefore studied the association of -344T/C polymorphism of the CYP11B2 gene with the presence and severity of hypertension in a case-control study.

We studied 369 individuals, of whom 213 were hypertensive patients (139 controlled hypertensive, 74 resistant hypertensive) and 156 were healthy normotensive subjects.

Keywords

• Aldosterone synthase
• hypertension
• polymorphism
• aldosterone
• -344T/C