Beta-3 agonist-induced lipolysis and nitric oxide production: relationship to PPARgamma agonist/antagonist and AMP kinase modulation

Abstract

In results have shown that both PPARgamma agonist and antagonist produced the same results supporting the theory, that the blockade is indeed non PPARgamma-dependent. Moreover, the effect is AMPK-dependent as AMPK blocker attenuated both effect of PPARgamma agonist and antagonist on Beta-3-triggered lipolyses and NO production.

Keywords

• nitric oxide
• lipolysis
• adipocytes
• beta-3 agonists
• troglitazone
• PPAR-gamma