Rozdílný serinový a glycinový metabolismus u pacientů se schizofrenií léčených klozapinem

Abstrakt

Dysfunction of the N-methyl-D-aspartate receptor, which is modulated by excitatory amino acids (EAA), is involved in the pathophysiology of schizophrenia. The effects of antipsychotics on EAA metabolism are uncertain.

Positive clinical effects of treatment with antipsychotics were not always associated with changes in EAA serum levels in patients with schizophrenia in clinical trials.

Klíčová slova

• serine
• clycine
• schizophrenia
• clozapine
• excitatory amino acids
• antipsychorics
• conventional neuroleptics