Serum Metabolomics Reveals Irreversible Inhibition of Fatty Acid beta-Oxidation through the Suppression of PPAR alpha Activation as a Contributing Mechanism of Acetaminophen-Induced Hepatotoxicity

Abstract

Metabolomic analysis of acetaminophene induced hepatotoxicity in mice revealed that the CYP2E1-mediated metabolic activation and oxidative stress can cause irreversible inhibition of fatty acid oxidation, potentially through suppression of PPAR alpha

Keywords

• MITOCHONDRIAL PERMEABILITY TRANSITION
• ACUTE LIVER-FAILURE
• MASS-SPECTROMETRY
• EARLY PREDICTOR
• MICE
• TOXICITY
• MOUSE
• METABOLISM
• IDENTIFICATION
• PARACETAMOL