Development of a fast LC-MS/MS method for quantification of rilmenidine in human serum: elucidation of fragmentation pathways by HRMS

Abstract

A sensitive method using liquid chromatography–tandem mass spectrometry for determination of rilmenidine in human serum was developed. This assay was successfully used to determine the drug levels in patients in real clinical setting.

Keywords

• Rilmenidine
• LC-MS/MS
• serum
• quantification
• HRMS