Determination of doxazosin and verapamil in human serum by fast LC-MS/MS: Application to document non-compliance of patients

Abstract

A sensitive method using liquid chromatography–tandem mass spectrometry for determination of doxazosin ans verapamil in human serum was developed. This assay was successfully used to determine noncompliance of patients in real clinical setting.

Keywords

• Doxazosine
• verapamil
• hypertension