The incidence of potential periodontal pathogens was monitored in patients with chronic periodontitis and healthy controlsubjects.Two types of studies were carried outin which the composition of the bacterial communities in different niches of the same oral cavity ecosystem was investigated.A relatively high incidence of the tested periopathogens in the clinicaly healthy teeth of patients implies that even the "healthy"niches in the periodontal biotope functionas a dynamic reservoir of periopathogenic microorganisms.This should be kept in mind when a local application of antibacterial compounds is used in the therapy of periodontal disease