Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors

Abstract

Minimal pharmacophoric elements and fragment hopping, an approach directed at molecular diversity and isozyme selectivity. Design of selective neuronal nitric oxide synthase inhibitors

Keywords

• DE-NOVO DESIGN
• AMIDE BOND PEPTIDOMIMETICS
• DECISION-MAKING PROCESS
• BINDING-SITES
• DRUG DISCOVERY
• LEAD DISCOVERY
• IN-SITU
• COMBINATORIAL CHEMISTRY
• STRUCTURAL MODIFICATION
• CHEMICAL LIBRARIES