Hepatoprotective Effect of MMP-19 Deficiency in a Mouse Model of Chronic Liver Fibrosis

Abstract

Liver fibrosis is characterized by the deposition and increased turnover of extracellular matrix. This process is controlled by matrix metalloproteinases (MMPs), whose expression and activity dynamically change during injury progression.

Keywords

• HUMAN MATRIX-METALLOPROTEINASE
• HEPATIC STELLATE CELLS
• DIFFERENTIAL EXPRESSION
• RHEUMATOID-ARTHRITIS
• TUMOR INVASION
• TGF-BETA
• RAT
• SURFACE
• INJURY
• PROLIFERATION