Glycol porphyrin derivatives as potent photodynamic inducers of apoptosis in tumor cells.

Abstract

The design and synthesis of glycol-functionalized porphyrins that contain one to four low molecular weight glycol chains and the comparison of fluorinated and nonfluorinated para derivatives are reported. The ethylene glykol chain at the meta position exhibits a superior efficacy in human breast carcinoma (MDA-MB-231) therapy.

Keywords

• BREAST-CANCER CELLS
• IN-VITRO
• SACCHARIDE RECOGNITION
• MEDICINAL CHEMISTRY
• ANTICANCER THERAPY
• LEUKEMIC-CELLS
• PHOTOSENSITIZERS
• NECROSIS
• PHTHALOCYANINE
• MECHANISMS