Porphyrin-Cyclodextrin Conjugates as a Nanosystem for Versatile Drug Delivery and Multimodal Cancer Therapy

Abstract

The porphyrin-cyclodextrin conjugates were prepared and tested for selective and effective multi-functional drug delivery and therapy. The porphyrin receptor system combines efficient binding of the selected drug to the cyclodextrin cavity and photosensitizing properties of the porphyrin moiety with high accumulation of the whole complex in cancer tissue.

The combined effect of chemotherapy and photodynamic therapy is demonstrated by in vitro and in vivo studies.

Keywords

• MOLECULAR RECOGNITION THERMODYNAMICS
• IN-VITRO
• PHOTODYNAMIC THERAPY
• BETA-CYCLODEXTRIN
• BRIDGED BIS(BETA-CYCLODEXTRIN)S
• SACCHARIDE RECOGNITION
• COOPERATIVE BINDING
• TUMOR-CELLS
• PHOTOSENSITIZERS
• RECEPTORS