Tandem mass spectrometry of sphingolipids: Application in metabolic studies and diagnosis of inherited disorders of sphingolipid metabolism

Abstract

Tandem mass spectrometry is efficient to establish metabolomic profiles of sphingolipids in various biological materials under normal and abnormal conditions. It contributes to better understanding of the biological significance of sphingolipid molecule.

Keywords

• tandem mass spectrometry
• sphingolipids in tissues
• cells and urine
• sphingolipid profiling
• lysosomal storage disorders
• globotriaosylceramide
• GM1 ganglioside
• sulfatide
• glucosylceramide
• Fabry and Gaucher diseases
• prosaposin and saposin B deficiencies
• metachromatic leucodystrophy