Childhood near-tetraploid acute lymphoblastic leukemia: an EGIL study on 36 cases

Abstract

Patients with near-tetraploid (karyotype: 81 - 103 chromosomes) acute lymphoblastic leukemia (NT-ALL) constitute about 1% of childhood ALL and data reported on them are limited and controversial. The aim of the study was to enlarge the knowledge on these rarely occurring ALL.

Methods: The members of the European Group for Immunophenotyping of Leukemias (EGIL) searched retrospectively their databases for NT-ALL patients. Results: We collected data of 36 European children from seven European countries with NT-ALL diagnosed since 1992.

All patients reached complete remission (CR) after induction chemotherapy.

Keywords

• tetraploid acute lymphoblastic leukemia
• polyploidy
• childhood
• classification
• immunophenotyping
• molecular genetics
• prognosis
• acute myeloid leukemias
• nordic countries
• expression
• children
• fusion
• classification
• reduction
• diagnosis
• impact
• trials