Comparative metabolism of cyclophosphamide and ifosfamide in the mouse using UPLC-ESI-QT0FMS-based metabolomics
2010
Abstract
Two common chemotherapeutic agents, Ifosfamide and cyclophosphamide, are isomers, bu only ifosfamide is known to cause nephrotoxicity and neurotoxicity. UPLC-ESI-QT0FMS-based metabolomics revealed five novel metabolites.
The results suggest that precursors of thiodiglycolic acid, may be responsible for Ifosfamide encephalopathy and nephropathy.
Keywords
Ifosfamide Cyclophosphamide Metabolomics Ultra-performance liquid chromatography Time-of-flight mass spectrometry Tandem mass spectrometry CHROMATOGRAPHY-PHOTOGRAPHY-DENSITOMETRY BIOLOGICALLY-ACTIVE METABOLITE CONTINUOUS-INFUSION MASS-SPECTROMETRY METHYLENE-BLUE PHOSPHORAMIDE MUSTARD URINARY METABOLITES MAGNETIC-RESONANCE CANCER-PATIENTS IDENTIFICATION