Family history and lung cancer risk: international multicentre case-control study in Eastern and Central Europe and meta-analyses

Abstract

We investigated family history of cancer among first-degree relatives of 2,861 patients with lung cancer and 3,118 controls from the Czech Republic, Hungary, Poland, Romania, Russia, Slovakia, and United Kingdom within the IARC Multicenter Case-Control Study. In addition, we conducted a meta-analysis of 41 studies on FH of cancer and lung cancer risk.

The results of meta-analysis were consistent with that of our study with regard to young onset, non-smokers and histology. FH of lung cancer is a predictor of an increased risk of lung cancer, especially in subjects aged less than 50.

Keywords

• Lung cancer
• Family history
• Case-control study
• Meta-analyses
• complex segregation analysis
• nonsmoking chinese women
• susceptibility locus
• respiratory-disease
• publication bias
• never-smokers
• united-states
• relatives
• aggregation
• smoking