A novel recurrent chromosomal aberration involving chromosome 7 in childhood myelodysplastic syndrome
2010
Abstract
We present an unusual cytogenetic abnormality leading to loss of both the whole short and whole long arms of chromosome 7, which was found in the bone marrow cells of three pediatric patients with MDS. Using a combination of conventional and molecular cytogenetic methods, a tiny 'dot-like' marker chromosome was found and described as der(7)del(7)(p11)del(7)(q11).
Together with one previously published case, this chromosomal aberration represents a new rare recurrent karyotypic abnormality involving chromosome 7 in children with MDS.