Publication
Abstract
Our experiment confirmed growth and metastatic spread in both murine groups. Removed tumors differed in volume; average weight was 0,62 g in PAR2-/- and 0,4 g in control animals.
Metastatic spread was observed in both groups and reached 80% in PAR2-/- and 50% in control animals. Whether in control mice, only lung metastases were observed, local tumor recurrence, renal and lung metastases were observed in PAR2-/- mice.
The absence of functional PAR-2 could be an important factor influencing the growth and spread of melanoma in vivo probably due to process of tumor cells migration, invasiveness and metastasis formation.