Antitumor Effects and Cytotoxicity of Recombinant Plant Nucleases.

Abstract

Recombinant plant nucleases R-TBN1 and R-HBN1 were isolated to homogeneity and examined for their antitumor effects and cytotoxicity. The nucleases were strongly cytostatic in vivo, ( against human melanoma tumors growing in nude mice), after their intravenous administration as stabilised conjugates with polyethylene glykol (PEG).

Keywords

• Anticarcinogenic and antiproliferative nuklease human melanoma
• tumor xenografts
• spermatogenesis
• Nicotiana benthamina
• plant infiltration
• L. esculentum
• H. lupulus