Abstrakt
Measurement of the size of the pupil is used as a biomarker of drug efficacy. The aim of our study was to evaluate sensitivity of various pupilometric parameters as biomarkers of widely used opioid analgesic drug tramadol.
Pharmacodynamic action was studied in 60 healthy volunteers. Commercially available infrared pupilometer 'Pupilscan II' was used for the measurements of static and dynamic pupilometric parameters prior the dosing and 2.5 hours afterwards.
Drug-induced decreases of the initial diameter (0, 49 mm) a final diameter (0, 38 mm) were significant in the right eye, as well as in left eye. Our results confirm the use of pupilometric as an objective, non-invasive tool for evaluation of pharmacodynamic activity of drugs.