Prognosis of children with mixed phenotype acute leukemia treated on the basis of consistent immunophenotypic criteria
2010
Abstract
Simple immunophenotypic criteria were used to classify all cases of childhood acute leukemia in order to provide therapy directed against acute lymphoblastic leukemia or acute myeloid leukemia. Prognosis, genotype and immunoglobulin/T-cell receptor gene rearrangement status were analyzed.
Keywords
pediatric acute lymphoblastic leukemia pediatric acute myeloid leukemia mixed phenotype leukemia biphenotypic leukemia aberrant antigens cytometry acute hybrid leukemia acute lymphoblastic leukemias biphenotypic acute leukemia minimal residual disease receptor gene rearrangements activating FLT3 mutations acute myeloid leukemia myeloperoxidase activity fusion gene childhood differentiation