Abstract
Diabetic nephropathy,which affects approximately 35% of patients with type 1 and type 2 diabetes mellitus,is characterized by increasing excretion of albumin in the urine, increasing blood pressure and a gradual reduction of renal function, which can lead up to chronic renal failure.Treatment of diabetic nephropathy includes dietary measures, effective glycemic control,affecting of microalbuminuria and proteinuria and optimal control of blood pressure.First choice treatment is pharmacological blockade of the renin-angiotensin-aldosterone system.As demonstrated in numerous clinical studies ACE inhibitors and AT1 receptor antagonists for angiotensin II (AT1 blockers) have nephroprotective action.Early treatment of incipient stage of diabetic nephropathy (with regression of microalbuminuria)is a prevention of occurrence and progression of manifested diabetic renal damage.Indicator of effective treatment usually requiring a combination of multiple drugs is the target blood pressure of <130/80 m